A study on in vitro dissolution of cephradine in presence of mango juice.
Mallik J.
Journal of Global Pharma Technology 4 : 24-29
Abstract : Cephradine is a first generation semi-synthetic cephalosporin antibiotic, is widely used in clinics for its activity against both Gram-positive and Gram-negative bacteria. It is indicated for the treatment of urinary tract infections, skin and skin structure infections, respiratory tract infections and otitis media. Interaction of cephradine with mango juice were investigated by UV-spectrophotometer in simulated gastric juice (pH 1.2&3.2). In this research work, cephradine capsules were collected from drug shops. The samples were analyzed according to British Pharmacopoeia (BP) method 3. In this work in vitro dissolution studies were carried out in 900 ml of acidic buffer (pH 1.2&3.2) in a dissolution tester with a speed of 51 rpm at 37±0.5°C for six hours. The absorbance was measured by using UV-spectrophotometer at a ?max of 254nm. Compare with the absorbance of drug and the drug in presence of mango juice simulated gastric juice (pH 1.2&3.2). The drug release kinetics was also measured. It is observed from the drug release profile that, there is no significant difference in the drug release curve of pH 1.2&3.2.