| Patent Information | : | 101669934 |
|---|---|---|
| Title | : | Suppressive activity of mango aglycone on PTP1B and application thereof |
| Author | : | Nanjing University |
| Field belongs to | : | Medicine |
| Abstract | : | The invention belongs to the technical field of biological pharmacy, and in particular relates to suppressive activity detection of tetrahydroxy norathyriol on protein-tyrosine-phosphatase (PTP) 1B, improvement of resistance function of insulin and accpication in medicament for PTP1B related diseases. Proved by in vitro enzyme suppression experiments, the invention testifies that mango aglycone isthe competitive suppressant of restructuring humanized PTP1B with IC50 value being 9.2 mu m; mango aglycone can ensure the sensitivity of C57BL/6 normal mo |